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Further Recommended Reading:
Fish Diseases | How to Treat Sick Fish
TRUE Aquarium UV Sterilization; How to Use a UV-C Sterilizer

Aquarium Information
-A great source for current aquarium information that is updated regularly as new research become available.

Nitrofurazone, Furan 2; For Aquarium, Pond

Nitrofurazone, Furan 2

Revised 1/16/19

This article is copied in part courtesy:
Aquarium Medications 2, Antibiotics/ Anti-microbials

Nitrofurazone also known as Nitrofural, is a broad-spectrum bactericidal drug, with some anti-protozoal activity. Nitrofurazone can be used both therapeutically (treatment) and prophylactically (prevention).

Nitrofurazone inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate.

This antibacterial is effective for control of: Aeromonas (Symptoms: fish have blisters forming on the skin that are full of a clear to yellowish fluid. The blisters may turn into large sores.), Vibrio and related bacterial species.
AND partly effective Flexibacter/Columnaris (Symptoms: Fuzzy, thin, white coating on the body and fins. Looks like a fungus) it works well with Kanamycin (best used in AAP Spectrogram) for difficult incidences of this pathogen,


Nitrofurazone (Nitrofural) is particularly useful for control of minor topical skin infections of freshwater & marine fish that have not become systemic.
As well, Nitrofurazone is effective for surface skin infections of Streptococcus iniae which may appear as a milky peeling slime.
Effective as well against marine external ulcer disease and some protozoan infestations. For this reason, Nitrofurazone is a good next step treatment for wounds and other topical infections when first step treatments such as Pimafix or Melafix fail.
Nitrofurazone is also useful in treating Furunculosis found in Koi (best treated in a small "kid pool" or bathtub with a seasoned Sponge Filter).

Serious adverse reactions related to general nitrofurans are very rare in aquarium or pond fish. Acquired resistance of bacteria to nitrofurans during therapy has been rare and has not appeared on a significant scale in over 50 years of use.
Do not use in the presence of invertebrates.


*Nitrofurazone is more effective at lower pH levels. Nitrofurazone is not Skin absorbed, so use of this Bactericidal for systemic infections is not recommended.
However Aquatronics and myself have found that Nitrofurazone combines well with Kanamycin (which is skin absorbing), and is very complimentary/synergistic to each other when used concurrently since Nitrofurazone is often effective topically for Aeromonas & Furunculosis while Kanamycin is required to be combined for Columnaris. Since these bacterial infections are often hard to differentiate by the average aquarist, this can be a good combination when unsure.

*As noted, Nitrofurazone can be combined with Kanamycin/Kanaplex to make an even more wide spectrum treatment, especially for difficult cases of Columnaris or Aeromonas.
Or better, the already superior blended synergistic combination found in AAP Spectrogram provides for an easier to use and more importantly, more synergistic and effective combination since these two medications are already blended and are not used in a somewhat conflicting treatment regimen as in the Kanaplex/Furan 2 combination which is less effective than Spectrogram due to the lack of concurrent use lowering the synergistic combination affect.
AAP Spectrogram Nitrofurazone and Kanaplex combination

*Spectrogram (Nitrofurazone/Kanamycin)can be combined with Metronidazole for parasitic, fungal, & bacterial infections; this duplicates the popular Aquatronics product “Paragon 2” that is no longer available.

Please realize diagnostic charts are generalizations.
Please click on the picture to enlarge for better view

Aquarium Pharmaceuticals Furan 2 Diagnostic Chart

"API Furan Two" (Nitrofurazone + Furazolidone) can be purchased here (A business with professional aquarium medication experience dating back to 1978):
Furan 2

OR BETTER, this wide spectrum blended combination:
AAP Spectrogram; Kanamycin/Nitrofurazone Wide Spectrum Combination

Source for Kanamycin: Kanaplex

Suggested other aquarium information resources & products:

Fish Diseases, How to Treat Sick Fish
Fish Diseases | How to Treat Sick Fish

Freshwater Aquarium Care
Freshwater Aquarium Care

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