Nitrofurazone, Furan 2; For Aquarium, Pond
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Aquarium Medications 2, Antibiotics/ Anti-microbials
Nitrofurazone also known as Nitrofural, is a broad-spectrum bactericidal drug, with some anti-protozoal activity. Nitrofurazone can be used both therapeutically (treatment) and prophylactically (prevention).
Nitrofurazone inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate.
This antibacterial is effective for control of Flexibacter/Columnaris (Symptoms: Fuzzy, thin, white coating on the body and fins. Looks like a fungus) it works well with Kanamycin for difficult incidences of this pathogen, Aeromonas (Symptoms: fish have blisters forming on the skin that are full of a clear to yellowish fluid. The blisters may turn into large sores.), Vibrio and related bacterial species.
Nitrofurazone (Nitrofural) is particularly useful for control of minor topical skin infections of freshwater & marine fish that have not become systemic.
As well, Nitrofurazone is effective for surface skin infections of Streptococcus iniae which may appear as a milky peeling slime.
Effective as well against marine external ulcer disease and some protozoan infestations. For this reason, Nitrofurazone is a good next step treatment for wounds and other topical infections when first step treatments such as Pimafix or Melafix fail.
Nitrofurazone is also useful in treating Furunculosis found in Koi (best treated in a small "kid pool" or bathtub with a seasoned Sponge Filter).
Serious adverse reactions related to general nitrofurans are very rare in aquarium or pond fish. Acquired resistance of bacteria to nitrofurans during therapy has been rare and has not appeared on a significant scale in over 50 years of use.
Do not use in the presence of invertebrates.
*Nitrofurazone is more effective at lower pH levels. Nitrofurazone is not Skin absorbed , so use of this Bactericidal for systemic infections is not recommended. However Aquatronics and myself have found that Nitrofurazone combines well with Kanamycin (which is skin absorbing), and is very complimentary to each other as wells since Nitrofurazone is often better topically for Aeromonas while Kanamycin is generally more effective for Columnaris, and since these bacterial infections are often hard to differentiate by the average aquarist, this can be a good combination when unsure.
*Nitrofurazone can be combined with Kanaplex to make an even more wide spectrum treatment, especially for difficult cases of Columnaris or Aeromonas.
This duplicates the popular Aquatronics product “Spectrogram” that is no longer available.
*Nitrofurazone can be combined with Kanaplex & Metronidazole for parasitic, fungal, & bacterial infections; this duplicates the popular Aquatronics product “Paragon 2” that is no longer available.
Please realize diagnostic charts are generalizations.
Please click on the picture to enlarge for better view
"API Furan Two" (Nitrofurazone + Furazolidone) can be purchased here (A business with professional aquarium medication experience dating back to 1978):